Research Achievements

Scientific Articles

Time-series blood cytokine profiles correlate with treatment responses in triple-negative breast cancer patients


Kosuke Kawaguchi, Don Saldajeno, Shinpei Kawaoka, Norikazu Masuda, Sunao Tanaka, Hiroko Bando, Tomomi Nishimura, Takayuki Kadoya, Takashi Yamanaka, Shigeru Imoto, Ravindranath Velaga, Nobuko Tamura, Tomoyuki Aruga, Kazushi Ikeda, Yurina Maeshima, Masahiro Takada, Eiji Suzuki, Takayuki Ueno, Seishi Ogawa, Hironori Haga, Shinji Ohno, Satoshi Morita, Masakazu Toi, and Yukiko Fukui


British Journal of Cancer


https://doi.org/10.1038/s41416-023-02527-0

Changes in cell-free DNA after short-term palbociclib and fulvestrant treatment for advanced or metastatic hormone receptor-positive and human epidermal growth factor 2-negative breast cancer Breast Cancer Research and Treatment 


Takayuki Iwamoto, Naoki Niikura, Kenichi Watanabe, Takashi Takeshita, Yuichiro Kikawa, Kokoro Kobayashi, Nobutaka Iwakuma, Takuho Okamura, Hiroshi Tada, Shinji Ozaki, Toshitaka Okuno, Uhi Toh, Yutaka Yamamoto, Michiko Tsuneizumi, Hiroshi Ishiguro, Norikazu Masuda, Shigehira Saji


Breast Cancer Research and Treatment


https://doi.org/10.21203/rs.3.rs-2909789/v1

Fulvestrant with or without anti-HER2 therapy in patients in a postmenopausal hormonal state and with ER-positive HER2-positive advanced or metastatic breast cancer: a subgroup analysis of data from the Safari study (JBCRG-C06)


Misato Masuyama, Norikazu Masuda, Hidetoshi Kawaguchi, Yutaka Yamamoto, Shigehira Saji, Takahiro Nakayama, Kenjiro Aogi, Keisei Anan, Shoichiro Ohtani, Nobuaki Sato, Toshimi Takano, Eriko Tokunaga, Seigo Nakamura, Yoshie Hasegawa, Masaya Hattori, Tomomi Fujisawa, Satoshi Morita, Miki Yamaguchi, Toshinari Yamashita, Daisuke Yotsumoto, Masakazu Toi, Shinji Ohno


Cancer Medicine. 2023;00:1–13. 


https://doi.org/10.1002/cam4.6390

Interrupting Endocrine Therapy to Attempt Pregnancy after Breast Cancer


Ann H Partridge, Samuel M Niman, Monica Ruggeri, Fedro A Peccatori, Hatem A Azim Jr, Marco Colleoni, Cristina Saura, Chikako Shimizu, Anna B Sætersdal, Judith R Kroep, Audrey Mailliez, Ellen Warner, Virginia F Borges, Frédéric Amant, Andrea Gombos, Akemi Kataoka, Christine Rousset-Jablonski, Simona Borstnar, Junko Takei, Jeong E Lee, Janice M Walshe, Manuel Ruíz-Borrego, Halle C F Moore, Christobel Saunders, Vesna Bjelic-Radisic, Snezana Susnjar, Fatima Cardoso, Karen L Smith, Teresa Ferreiro, Karin Ribi, Kathryn Ruddy, Roswitha Kammler, Sarra El-Abed, Giuseppe Viale, Martine Piccart, Larissa A Korde, Aron Goldhirsch, Richard D Gelber, Olivia Pagani; International Breast Cancer Study Group; POSITIVE Trial Collaborators


New England Journal of Medicine 2023 May; 388:1645-1656


https://www.nejm.org/doi/full/10.1056/NEJMoa2212856

Adjuvant olaparib in the subset of patients from Japan with BRCA1- or BRCA2-mutated high-risk early breast cancer from the phase 3 OlympiA trial


Hideko Yamauchi, Masakazu Toi, Shin Takayama, Seigo Nakamura, Toshimi Takano, Karen Cui, Christine Campbell, Liesbet De Vos, Charles Geyer Jr, Andrew Tutt


Breast Cancer, 2023 April; 30, 596-605.


https://doi.org/10.1007/s12282-023-01451-8

Retrospective study on the effectiveness of medroxyprogesterone acetate in the treatment of ER-positive/HER2-negative postmenopausal advanced breast cancer: An additional analysis of the JBCRG-C06 Safari study


Hidetoshi Kawaguchi, Yutaka Yamamoto, Shigehira Saji, Norikazu Masuda, Takahiro Nakayama, Kenjiro Aogi, Keisei Anan, Shoichiro Ohtani, Nobuaki Sato, Toshimi Takano, Eriko Tokunaga, Seigo Nakamura, Yoshie Hasegawa, Masaya Hattori, Tomomi Fujisawa, Satoshi Morita, Miki Yamaguchi, Toshinari Yamashita, Daisuke Yotsumoto, Masakazu Toi, Shinji Ohno


Japanese Journal of Clinical Oncology. 2023 Mar; 53(3): 203–211


https://doi.org/10.1093/jjco/hyac184

Fulvestrant plus palbociclib in advanced or metastatic hormone receptor‑positive/ human epidermal growth factor receptor 2‑negative breast cancer after fulvestrant monotherapy: Japan Breast Cancer Research Group‑M07 (FUTURE trial)


Kenichi Watanabe, Naoki Niikura, Yuichiro Kikawa, Mari Oba, Kokoro Kobayashi, Hiroshi Tada, Shinji Ozaki, Uhi Toh, Yutaka Yamamoto, Michiko Tsuneizumi, Toshitaka Okuno, Nobutaka Iwakuma, Takashi Takeshita, Takayuki Iwamoto, Hiroshi Ishiguro, Norikazu Masuda, Shigehira Saji


Breast Cancer Research and Treatment. 2023 Mar; 199: 253–263


https://doi.org/10.1007/s10549-023-06911-5

Factors affecting prognosis in patients treated with bevacizumab plus paclitaxel as first-line chemotherapy for HER2-negative metastatic breast cancer: an international pooled analysis of individual patient data from four prospective observational studies Breast Cancer


Yutaka Yamamoto, Hiroyasu Yamashiro, Andreas Schneeweiss, Volkmar Müller, Oleg Gluz, Peter Klare, Bahriye Aktas, Magdolna Dank, László Büdi, Béla Pikó, László Mangel, Masakazu Toi, Satoshi Morita, Shinji Ohno


Breast Cancer. 2022 Sep; Online publish. Volume 30, pages88–100 (2023).


https://doi.org/10.1007/s12282-022-01399-1

Pertuzumab retreatment for HER2-positive advanced breast cancer: a randomized, open-label phase III study


Yutaka Yamamoto, Hiroji Iwata, Naruto Taira, Masato Takahashi, Tetsuhiro Yoshinami, Takayuki Ueno, Tatsuya Toyama, Takashi Yamanaka, Toshimi Takano, Masahiro Kashiwaba, Norikazu Masuda, Koichiro Tsugawa, Yoshie Hasegawa, Kenji Tamura, Hiroshi Tada, Fumikata Hara, Tomomi Fujisawa, Naoki Niikura, Shigehira Saji, Satoshi Morita, Masakazu Toi, Shinji Ohno


Cancer Science. 2022 Jun; Online publish. 2022;113:3169–3179.


https://doi.org/10.1111/cas.15474

Switch maintenance endocrine therapy plus bevacizumab after bevacizumab plus paclitaxel in advanced or metastatic oestrogen receptor-positive, HER2-negative breast cancer (BOOSTER): a randomised, open-label, phase 2 trial


Shigehira Saji, Naruto Taira, Masahiro Kitada, Toshimi Takano, Masahiro Takada, Tohru Ohtake, Tatsuya Toyama, Yuichiro Kikawa, Yoshie Hasegawa, Tomomi Fujisawa, Masahiro Kashiwaba,, Takanori Ishida,Rikiya Nakamura, Yutaka Yamamoto, Uhi Toh, Hiroji Iwata, Norikazu Masuda, Satoshi Morita, Shinji Ohno, Masakazu Toi


Lancet Oncology. 2022 May; 23(5): 636-649.


https://doi.org/10.1016/S1470-2045(22)00196-6

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by Voluntary Organization JBCRG